The therapeutic effects of sodium cromoglycate against influenza A virus H5N1 in mice
نویسندگان
چکیده
منابع مشابه
The therapeutic effects of sodium cromoglycate against influenza A virus H5N1 in mice
OBJECTIVES To identify the protective role of sodium cromoglycate in mice during influenza virus infection. DESIGN H5N1 virus-infected mice were treated with the mast cell stabilizer sodium cromoglycate (SCG) to investigate its therapeutic effect. SAMPLE The nose, trachea and lungs from mice were collected. MAIN OUTCOME MEASURES Virus replication and host responses were determined by plaq...
متن کاملProphylactic and Therapeutic Efficacy of Avian Antibodies Against Influenza Virus H5N1 and H1N1 in Mice
BACKGROUND Pandemic influenza poses a serious threat to global health and the world economy. While vaccines are currently under development, passive immunization could offer an alternative strategy to prevent and treat influenza virus infection. Attempts to develop monoclonal antibodies (mAbs) have been made. However, passive immunization based on mAbs may require a cocktail of mAbs with broade...
متن کاملBacillus subtilis as a Host for Recombinant Hemagglutinin Production of the Influenza A (H5N1) Virus
Abstract Background and Aims: Influenza A(H5N1) viruses circulating in animals might evolve and acquire the ability to spread from human to human and thus start a pandemic. Hemagglutinin (HA) has been shown to play a major role in binding of influenza virus to its target cell and the main neutralizing antibody responses elicit against this region. Recent studies have shown that...
متن کاملIn vitro and in vivo effects of Peganum harmala L. seeds extract against influenza A virus
Objective: Influenza A virus infections are still a major health problem and the choices available for the control and treatment of the disease are limited. This research evaluated in vitro and in vivo antiviral effects of Peganum harmala L. seeds (PHS) extract against influenza A virus. Materials and Methods: In this research, in vitro anti-influenza A virus activity of the extract was assesse...
متن کاملMolecular correlates of influenza A H5N1 virus pathogenesis in mice.
Highly pathogenic avian influenza A H5N1 viruses caused an outbreak of human respiratory illness in Hong Kong. Of 15 human H5N1 isolates characterized, nine displayed a high-, five a low-, and one an intermediate-pathogenicity phenotype in the BALB/c mouse model. Sequence analysis determined that five specific amino acids in four proteins correlated with pathogenicity in mice. Alone or in combi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Influenza and Other Respiratory Viruses
سال: 2015
ISSN: 1750-2640,1750-2659
DOI: 10.1111/irv.12334